ncRNA name | hsa-miR-589-5p |
ncRNA Category | miRNA |
Disease name | age-related cataract |
Species | Homo sapiens |
Tissues/Cell_line | human lens epithelial cell line SRA01/04 |
Methods | transfection, qRT-PCR, luciferase reporter assay |
Expression pattern | associated |
Functional description | The C allele of XPC-2229090 increase the risk with ARNC. The mechanism underlying might be due to the stronger interation of the C allele with hsa-miR-589-5p, resulting in lower XPC expression and DNA repair capability than the individuals carring G allele in lens. |
PubMed ID | 30315181 |
Year | 2018 |
Title | MicroRNA binding mediated Functional sequence variant in 3'-UTR of DNA repair Gene XPC in Age-related Cataract. |
Drug-related ncRNA | NO |
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